Cardiac insufficiency.

Proteasome functional insufficiency in cardiac pathogenesis.

The ubiquitin-proteasome system (UPS) is responsible for the degradation of most cellular proteins. Alterations in cardiac UPS, including changes in the degradation of regulatory proteins and proteasome functional insufficiency, are observed in many forms of heart disease and have been shown to play an important role in cardiac pathogenesis. In the past several years, remarkable progress in und...

Compensatory hyperfunction of the heart and cardiac insufficiency.

Multivariable prediction of renal insufficiency developing after cardiac surgery.

BACKGROUND Renal insufficiency after coronary artery bypass graft (CABG) surgery is associated with increased short-term and long-term mortality. We hypothesized that preoperative patient characteristics could be used to predict the patient-specific risk of developing postoperative renal insufficiency. METHODS AND RESULTS Data were prospectively collected on 11,301 patients in northern New En...

Renal insufficiency after cardiac surgery: a challenging clinical problem.

Acute renal insufficiency (ARI) after cardiac surgery is a complex and frequent clinical problem. It increases shortand long-term mortality, the incidence of post-operative complications such as respiratory infections, sepsis, and gastrointestinal bleeding, and intensive care unit (ICU) and hospital lengths of stay. Identified risk factors for post-operative ARI in cardiac surgical patients inc...

Cardiac performance in experimental adrenal insufficiency in cats.

Cardiac function was evaluated by ventricular function curves during the cardiovascular collapse observed in acute and chronic adrenal insufficiency. A progressive decline in peak cardiac work was observed in the acutely adrenalectomized cat (303; decrease at 1.8 hours and 50% at 3.5 hours after adrenalectomy). This impairment in cardiac work paralleled the decrease in mean arterial blood press...